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Pharmacology: Pharmacodynamics: Reduced viscosity of mucopurulent secretions: Mucotic HD contains Acetylcysteine is the N-acetyl derivative of the naturally occurring amino acid L-cysteine. Acetylcysteine reduces the viscosity of purulent and nonpurulent pulmonary secretions, through its free sulfhydryl group by cleaving the intramolecular disulfide bonds in mucoproteins aggregates.
Reduced toxicity of overdoses Paracetamol: Acetylcysteine is considered to reduce the hepatic toxicity, toxic intermediate metabolite following ingestion of a high dose of paracetamol. Acetylcysteine being provided with sulfhydryl group for maintains cellular glutathione at a level sufficient to conjugate with the toxic intermediate metabolite.
Pharmacokinetics: Following oral administration, Acetylcysteine is absorbed from the GI tract.
Distribution: 0.47 L/kg.
Protein binding, plasma: 83%.
Half-life elimination of total Acetylcysteine: 5.6 Hours (adult).
Time to peak, plasma: 1-2 hours.
Excretion: Urine.
Toxicology: Preclinical safety data: Not applicable.
